preparation and physicochemical evaluation of nystatine mucoadhesive buccal film

نویسندگان

rahim bahri najafi

mohammad eghbali

mohammad peykanpour

hamidreza mirzaei

چکیده

abstract: background: a new type of drug delivery system known as mucoadhesive film has been developed for oral thrush treatment. due to comfortable use of this drug delivery system, this would be encouragingly utilized, especially in babies and patient under chemotherapy. nystatin mucoadhesive film (nmf) is a polymeric film which is adhered to front upper gum and back to the upper lip and releases the drug within 5-6 hours in desired concentration. because of sustained-release nature and permanent contact of drug with infectious agent of candida albicans , the disease amelioration would be happened more rapidly while the patients can do routine activities such as eating, drinking and talking without any feeling of the existence of film in their mouth cavity. methods: nmf film was prepared using eudragit rl100 and hpmc as film-forming constituents, and glycerin, propylene glycol and poly ethylene glycol 400 as plasticizer, according casting method. finally, physical appearance, weight, in vitro drug release rate and adhesion were assessed. findings: in respect to considered parameters, prepared films with hpmc were not shown uniform appearance; however, prepared films with eudragit rl100 were shown more desirable results and later shown longer time of drug release with approximate time of 5.5 hours. discussion: prepared films with dimensions of 2×1 cm containing 10 mg nystatin using eudragit rl100 polymer with mixture of glycerin, propylene glycol as plasticizer, not only shown desirable pharmaceutics characteristics but also exponential value (n) of 0.779 showed non-fickian behavior of drug release.

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عنوان ژورنال:
journal of reports in pharmaceutical sciences

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